Editor gene helped two children to cure from cancer

Редактор генов помог двоих детей вылечить от рака

Editor of the genes successfully used in the treatment of cancer

Infants as well as chemotherapy and stem cell transplantation.

The technology for editing genes rescued two children, who suffered from an aggressive form of leukemia, reported in the journal Science Translational Medicine.

Two children aged 16 and 18 months were treated together a therapy based on chimeric antigen receptors, and the technology for genome editing.

Chimeric antigen receptors are proteins, which includes fragments of antibodies having the ability to bind with specific antigens with signaling domains capable of activating T-cells play an important role in the immune response.

This combination uses to fight cancer own immune cells of the patient, edited to successfully confront the disease.

However, the earlier the children have already received chemotherapy, as they were transplanted stem cells. Therefore, it is impossible to say how great was the contribution of this procedure in healing from cancer.

However, the doctors believe this approach is promising and potentially suitable for the treatment of cancer and noted the need for more clinical trials.

Last year it was reported that genetic editor CRISPR/Cas9 has allowed scientists to heal the adult mouse from a severe genetic disease – Duchenne muscular dystrophy.

For the first time, doctors managed to save a terminally ill leukemia a person with genetically modified cells in 2015.

According to the materials:

Newspaper.EN
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