Neuroscientists have uncovered the mystery of alcoholism

Нейробиологи раскрыли тайну алкоголизма

The researchers hope that their work will help in the development of new methods of treatment of alcoholism.

Neuroscientists from the University of North Carolina have discovered a chain of neural cells that might be responsible for the fatal passion for alcohol.

These chains combine two brain regions — the extended amygdala and the ventral tegmental area (SPM), which are known to be responsible for the stress response and dependencies, respectively. A study published in the journal Biological Psychiatry.

For the first time, neuroscientists were able to demonstrate that these two regions interact with one another via neural circuitry. These networks consist of projection neurons — nerve cells with long nerve that is able to transmit signals to other brain areas.

Experiments on mice have shown that suppression of the activity of circuits between two regions of the brain protects against overeating and alcohol consumption. Thus, CRF-system (corticotropin-releasing-hormones) was associated with the occurrence of alcoholism.

The extended amygdala is involved in reactions to psychological stress such as loss of a job or loved one, and the GP is involved in deriving pleasure from food and from drugs and alcohol.

Scientists have shown that alcohol activates CRF neurons in the extended amygdala, which transmit the excitation of GPS and, ultimately, contributing to further alcohol use.

The researchers hope that their work will help in the development of new methods of treatment of alcoholism or preventive measures against addiction among young people.

Previously, Finnish researchers have discovered a gene mutation, carriers of which are prone to violent and reckless behavior in an alcohol intoxication.

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