Scientists have discovered a gene that suppresses the craving for alcohol

Ученые обнаружили ген, который подавляет тягу к алкоголю

The research results will help create new treatments for alcoholism.

Genetics southwestern medical center the University of Texas have identified a gene that suppresses the desire to consume alcohol. The results presented in the article published in the journal Proceedings of the National Academy of Sciences.

Experts studied the results of several studies in which search was conducted of the link between addiction to alcohol and different variants (alleles) of genes.

In addition, the researchers compared the DNA of more than 105 thousand people. In this case, by hard drinking, participants were treated men who consume more than 21 glasses of alcohol a week and women who drink more than 14.

Moderate drinkers were those who consumed less than 14 cups (man) or less than seven (women).

It is established that one of the variants of the gene of β-Klotho was present in 40 percent of study participants (with a weak alcohol).

β-Klotho encodes a protein that forms in the Central nervous system complex protein complex. The latter is also formed by receptor molecules known as growth factors of fibroblasts 21 (FGF21).

The complex binds with the hormone FGF21, activating it, and that, in turn, directly affects the Central nervous system, suppressing the craving for alcohol.

Scientists have found a way to completely remove the craving for alcohol

FGF21 has been shown in other studies, may also decrease addiction to sugar, helps reduce weight. In addition, this compound up metabolism, circadian rhythms and female reproductive function.

However, for proper operation of the hormone required β-Klotho, as the mutant mice with inactive gene craving for alcohol did not disappear, even if they artificially increased the level of FGF21 in the blood.

Scientists hope that their findings will help create new treatments for alcoholism.

Previously, researchers found that the concentration of phosphatidylserine metabolite of alcohol in the postmortem brain samples can tell us about addiction to alcohol during his lifetime and intoxicated at the time of death.

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