Scientists have found a way to beat premature aging

Ученые нашли способ победить преждевременное старение

Progeria caused by a mutation of the gene LMNA

The symptoms of progeria occur in children aged two to three years and include muscle atrophy, skin aging, hair loss and bone loss.

Scientists of the St. Louis University in the US revealed the mechanism of rapid aging in children with progeria (a syndrome Hutchinson-Gilford). It is reported by EurekAlert! on Tuesday, March 20.

According to experts, this disease breaks down the process of cell division and the immune system. Vitamin D allows you to reverse the process.

The symptoms of progeria occur in children aged two to three years and include muscle atrophy, skin aging, hair loss and bone loss. As a rule, patients die from the disorders in the circulatory system due to atherosclerosis.

This disease is caused by mutation of the gene LMNA, which encodes Lamin a protein, which forms the underlying layer of the membrane of the cell nucleus. Defective form of lamina is called progeria, and it makes the core unstable.

The cell nucleus separates DNA from the rest of the cells and is involved in the replication (doubling) of the genes of realization of genetic information (expression) and other important processes. Wrong functioning of the nuclear apparatus leads to the accumulation of mutations that lead to aging and cancer.

Researchers have shown that the main cause of DNA damage in the syndrome of Hutchinson-Gilford is replication stress. It occurs when the mechanism responsible for the replication of nucleic acids, encounters some kind of obstacle does not allow further copying of the gene.

There are usually ways to bypass these barriers, however, progerin makes them ineffective. First, it makes the already replicated DNA is vulnerable to nucleases enzymes that cleave the nucleic acid. Second, progerin activates interferons to fight the DNA fragments that emerge from the nucleus, which causes inflammation.

Scientists have discovered that vitamin D can improve the condition of the cells, rejuvenating it. It blocks the activation of interferon and reduces replication stress.

Previously Sabalos that scientists in Finland have found a way to avoid premature death. a large-scale study lasted for 22 years.

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